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The new vaccine brings hope to millions of adults and infants older than 6 months, by protecting against typhoid fever caused by Salmonella typhi, a highly virulent and invasive enteric bacterium Hyderabad, India, August 26, 2013: Bharat Biotech (www.bharatbiotech.com) today announced the launch of World’s first clinically proven typhoid conjugate vaccine Typbar-TCV™ , a fourth generation vaccine against typhoid disease, proven to provide long term protection to adults and infants 6 months & older. Currently available Typhoid vaccines fall short in two major characteristics, namely long term protection and protection for children below 2 years of age, the population that needs it the ost.During its development since 2005 Typbar-TCV™ was evaluated in ~1200 healthy subjects at 9 clinical sites. In the pivotal ph III clinical study, Typbar-TCV™ presented 98% seroconversion in infants aged 6 months to 24 months, 99% in children between 2 to 15 years of age, and 92% in the 15 to 45 year age group, as measured by 4 fold increase in serum IgG responses. It proved to be superior to the Vi polysaccharide typhoid vaccines. Typbar-TCV™ was also safe and well tolerated in all tested age groups. “Typhoid fever remains an important public health challenge in many countries of the world mainly because of poor diagnostics and increasing resistance to antibiotics. At present fundamental prevention strategies like improved sanitation, good hygienic practices and access to clean water are still out of reach for many impoverished communities. One of the most cost effective approaches to prevent infectious diseases, are vaccines which are available now and could help control the disease resulting in reduction of unnecessary suffering and adverse financial consequences.” Dr. Christian Loucq, M.D., Director-General of the International Vaccine Institute (IVI) said.Typhoid fever is a life threatening illness caused by the bacterium Salmonella typhi, which is transmitted through food or drink contaminated by the faeces or urine of infected people. Symptoms include high fever, malaise, headache, constipation, diarrhoea, etc. Healthy carrier state may follow acute illness. It causes between 250,000 to 600,000 deaths and 20 million illnesses per year, affecting mostly school-age children. The World Health Organization reports 90 percent of typhoid deaths occur in Asia and persists mainly in children under 5 years of age. In India, Typhoid fever is observed throughout the year and a greater number of cases coincide with the rainy season. While typhoid fever can be cured by antibiotics, resistance to antimicrobials is widespread along with poor diagnostics, hence prevention of typhoid fever is better than the cure.cknowledging the effort of his team of scientists that led to this innovation Dr. Krishna M. Ella, Chairman and Managing Director of Bharat Biotech said “Bharat Biotech’s Typbar-TCV™ induces 'T' cell dependent response with much higher antibody levels providing a very high rate of immunity. We hope this vaccine will reach millions of people and help reduce the burden of this devastating disease in infants and children.” Dr. Ella added.Bharat Biotech has commenced commercial production of Typbar-TCV™ in pre-filled syringes in its world class vaccine production facility in Genome Valley. The plant has capacity to produce 10 million doses each year, expandable to 50 million doses per year in the future. Bharat Biotech is the largest producer and supplier of Vi typhoid vaccine in the world having distributed over 50 million doses globally. Typbar-TCV™ isavailable for supplies to global markets such as South East Asia, South America, Africa, entral Asia, and South Asia.